Leptospirosis vaccines in cattle

Leptospirosis is a zoonotic disease caused by bacteria of the Leptospira genus.

Leptospirosis is a common infection in dairy and beef herds and causes infertility, abortion and poor milk yield.

Infection arises from contact with infected urine or the products of abortion.

Two vaccines for leptospirosis were marketed in the UK in 2025:

• Leptavoid® -H contains inactivated Leptospira interrogans serovar Hardjo
• Spirovac contains inactivated Leptospira borgpetersenii serovar Hardjo type hardjobovis

The figures used to monitor estimated vaccine uptake are the number of doses of selected vaccines authorised for use in cattle and sheep sold in the UK each year.

These are based on wholesaler data collated by Kynetec and provided by MSD Animal Health.

Numerator

The number of doses administered has been calculated by multiplying the number of packs sold by the number of doses per pack.

Denominator

It was assumed that only female breeding animals should be vaccinated and that the at-risk population was all female cattle between one and two years of age, plus the total female breeding herd over two years of age.

Common industry practice is to give breeding heifers a primary course of vaccination (two doses) before first service, between the ages of one and two years, and to give all breeding females over two years of age a single annual booster vaccination.

To take this into account, the denominator was the number of breeding females over two years of age, plus the number of breeding heifers between one and two years of age multiplied by two.

Leptospirosis vaccine uptake has been relatively stable between 2011 and 2025, with around one in three of all breeding cattle over the age of one estimated to be vaccinated (Figure 1).

Estimated uptake decreased very slightly to 32% in 2025 (Figure 1), likely due to disruptions in the supply chain.

However, it is likely that uptake remained stable due to the use of imported leptospirosis vaccines.

Estimated vaccine uptake is based on sales data of UK authorised vaccines and does not include imported vaccine data.

Figure 1. Percentage of cattle vaccinated against leptospirosis 2011–2025